These measurements were conducted at each clinical site according to standardised procedures. BMI was calculated as weight divided by height squared (kg/m2). Waist and hip circumferences were averaged from two repeated measures with a non-stretch tape. Total body fat and its distribution (peripheral fat, VAT, SCAT) and lean mass and its distribution (appendicular lean mass) were estimated with a DEXA scan (Lunar Prodigy Advanced fan beam scanner, GE Healthcare, Bedford, United Kingdom; GE encore software, version 14.10.022 to 16, GE Medical Systems(21 (link))). Specifically, the DEXA system demarcated the boundaries of the android region based on an established protocol. VAT was estimated as part of the android region from an inbuilt algorithm of the DEXA software. SCAT was calculated after subtracting VAT from the android fat mass. These DEXA estimates of abdominal VAT and SCAT have been validated against amounts of VAT and SCAT determined by computed tomography(22 (link)) and magnetic resonance imaging(23 (link)), the reference methods for adipose tissue quantification.
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Standardized Measurement of Body Composition
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Corresponding Organization : University of Cambridge
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Variable analysis
independent variables
- BMI (calculated as weight divided by height squared (kg/m^2))
- Waist and hip circumferences (averaged from two repeated measures with a non-stretch tape)
- Total body fat and its distribution (peripheral fat, VAT, SCAT)
- Lean mass and its distribution (appendicular lean mass)
- None explicitly mentioned
- Standardized procedures for measurements at each clinical site
- DEXA scan (Lunar Prodigy Advanced fan beam scanner, GE Healthcare, Bedford, United Kingdom; GE encore software, version 14.10.022 to 16, GE Medical Systems) for estimating body composition
- Established protocol for DEXA system to demarcate the boundaries of the android region
- Inbuilt algorithm of the DEXA software to estimate VAT as part of the android region
- DEXA estimates of abdominal VAT and SCAT validated against computed tomography and magnetic resonance imaging (reference methods for adipose tissue quantification)
- None explicitly mentioned
- None explicitly mentioned
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