Manuscripts were selected or eliminated based on the following criteria:

Inclusion criteria:

Adult subjects with unilateral or bilateral lower
limb amputation

Published after August 1, 2007

Examined the relationship between predictive
variables recorded prior to amputee rehabilitation and
measures of walking ability following rehabilitation

Studies using health outcomes with a mobility
component, such as the Functional Independence
Measure

English language

Observational, retrospective studies if
predictor variables were available

Randomized clinical trials

Exclusion criteria:

Non-adult

Prosthetic device or rehabilitation
interventions studies

Animal studies

Case reports and series

Letters, editorials, conference proceedings

Manuscripts from developing nations

Two authors independently assessed selected papers for content, quality,
and critical appraisal. Similar to the original Sansam et al. SR, a standardized
checklist was used to extract each report’s methods, population, outcome
measures, and predictive factors (5 (link)).
Additionally, the UK National Service Framework for Long-term Conditions (3 ,9 )
was used to assess the quality of each study, as it allows assessment of quality
in non-randomized cohort studies. The reports and data extracted were verified
by at least two independent authors who agreed on final scoring and data
extraction. The International Classification of Functioning, Disability and
Health (4 ) was used to present the
predictive factors identified from these studies. Following study evaluation and
data extraction, factors predictive of walking ability following LEA were
aggregated and compared narratively with the findings of the original Sansam et
al. SR.