Pharmacological Evaluations of Novel Compounds

The following drugs were used in our experiments: polyinosinic–polycytidylic potassium salt (Sigma, P9582-5MG, batch #0000080809), JNJ47965567 (Tocris Bioscience), ITH15004 (personal contribution from Instituto Teófilo Hernando), and ARL 67156 trisodium salt (Tocris Bioscience, 1283, batch #16A/253182). All drugs were dissolved in sterile saline, except for JNJ47965567 and ITH15004, which were dissolved in 30% Captisol solution (sulfobutyl ether-7-cyclodextrin) and 5% DMSO, respectively.

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Mut-Arbona P., Huang L., Baranyi M., Tod P., Iring A., Calzaferri F., de los Ríos C, & Sperlágh B. (2023). Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development. The Journal of Neuroscience, 43(7), 1125-1142.

Publication 2023

JNJ47965567 ARL 67156 trisodium salt

Arl 67156 Captisol Cyclodextrin Dmso Drugs Ether Ith15004 Potassium Saline Salt Sterile

Corresponding Organization :

Other organizations : Semmelweis University, HUN-REN Institute of Experimental Medicine, Autonomous University of Madrid

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Variable analysis

independent variables

Polyinosinic–polycytidylic potassium salt (Sigma, P9582-5MG, batch #0000080809)
JNJ47965567 (Tocris Bioscience)
ITH15004 (personal contribution from Instituto Teófilo Hernando)
ARL 67156 trisodium salt (Tocris Bioscience, 1283, batch #16A/253182)

dependent variables

Not explicitly mentioned

control variables

Sterile saline (used as the solvent for polyinosinic–polycytidylic potassium salt)
30% Captisol solution (sulfobutyl ether-7-cyclodextrin, used as the solvent for JNJ47965567)
5% DMSO (used as the solvent for ITH15004)

positive controls

Not specified

negative controls

Not specified

Annotations

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