PCOS Metabolic Effects in Obese Adolescents

71 participants were enrolled; 41 with PCOS and 30 without. Inclusion criteria: female sex, obesity (BMI percentile >95%) and sedentary status (<3 hours of exercise/week; validated with both a 3 day activity recall and 7 day accelerometer use). Exclusion criteria: diabetes, alanine transferase (ALT) >80 IU/mL, BP >140/90 mmHg, hemoglobin <9mg/dl, serum creatinine >1.5 mg/dl, smoking, medications affecting IS (oral steroids, metformin, thiazolidinediones, atypical antipsychotics, hormonal contraceptives), antihypertensive medications, statins, pregnancy, and breastfeeding. PCOS was diagnosed per NIH criteria with adolescent adaptation: oligomenorrhea (<8 menses a year), clinical or biochemical signs of hyperandrogenism, and at least 2 years post-menarche (8 (link)). The study was approved by the University of Colorado AMC Institutional Review Board. Informed consent was obtained from all participants 18–20 years old, and parental consent and participant assent from all participants <18 years old.

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Cree-Green M., Bergman B.C., Coe G.V., Newnes L., Baumgartner A.D., Bacon S., Sherzinger A., Pyle L, & Nadeau K.J. (2016). Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but Insulin Resistance. Obesity (Silver Spring, Md.), 24(11), 2399-2406.

Publication 2016

Adaptation Adolescent Alanine Antihypertensive medications Antipsychotics Contraceptives Creatinine Diabetes Female sex Hemoglobin Hyperandrogenism Institutional review board Medications Menarche Menses Metformin Obesity Oligomenorrhea Pcos Pregnancy Recall Serum Statins Steroids Thiazolidinediones Transferase

Corresponding Organization : University of Colorado Anschutz Medical Campus

Other organizations : Colorado School of Public Health

Top 5 similar protocols

Protocol cited in 6 other protocols

Variable analysis

independent variables

PCOS (presence or absence)

dependent variables

Not explicitly mentioned

control variables

Female sex
Obesity (BMI percentile >95%)
Sedentary status (<3 hours of exercise/week; validated with both a 3 day activity recall and 7 day accelerometer use)
No diabetes
ALT ≤80 IU/mL
BP ≤140/90 mmHg
Hemoglobin ≥9mg/dl
Serum creatinine ≤1.5 mg/dl
No smoking
No medications affecting insulin sensitivity (oral steroids, metformin, thiazolidinediones, atypical antipsychotics, hormonal contraceptives)
No antihypertensive medications
No statins
No pregnancy
No breastfeeding

controls

Positive control: None mentioned
Negative control: None mentioned

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!