Ex vivo drug sensitivity testing

Ex vivo tests were described elsewhere [31 (link)]. Briefly, isolates of P. falciparum (parasitaemia ≥ 4000/μL to 200,000/μL) were collected before treatment and at day of recurrent parasitaemia. Drug sensitivity tests were performed within 24 h of bleeding, without culture adaptation using the modified isotopic micro-test technique [25 (link)]. The drugs tested were lumefantrine (Novartis Pharma, Basel, Switzerland), dihydroartemisinin (Sigma Tau., Rome, Italy) and monodesethylamodiaquine (WHO/TDR, Geneva, Switzerland).

Free full text: Click here

Lingani M., Bonkian L.N., Yerbanga I., Kazienga A., Valéa I., Sorgho H., Ouédraogo J.B., Mens P.F., Schallig H.D., Ravinetto R., d’Alessandro U, & Tinto H. (2020). In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso. Malaria Journal, 19, 8.

Publication 2020

lumefantrine

Adaptation Dihydroartemisinin Drug tests Drugs Isotopic Lumefantrine Monodesethylamodiaquine Parasitaemia Sensitivity

Corresponding Organization : Institut de Recherche en Sciences de la Santé

Other organizations : Centre Muraz, University of Amsterdam, Instituut voor Tropische Geneeskunde, MRC Unit the Gambia

Top 5 similar protocols

Variable analysis

independent variables

Lumefantrine (Novartis Pharma, Basel, Switzerland)
Dihydroartemisinin (Sigma Tau., Rome, Italy)
Monodesethylamodiaquine (WHO/TDR, Geneva, Switzerland)

dependent variables

Drug sensitivity

control variables

Isolates of P. falciparum (parasitaemia ≥ 4000/μL to 200,000/μL)
Drug sensitivity tests performed within 24 h of bleeding, without culture adaptation
Modified isotopic micro-test technique [25 (link)]

controls

No positive or negative controls mentioned.

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!