Synthesis and Characterization of Sazetidine-A

Sazetidine-A (6-(5-(S)-azetidin-2-yl)methoxypyridine-3-yl)hex-5-yn-1-ol) was synthesized according to published methods (Kozikowski et al. 2009 (link)). Mecamylamine hydrochloride, methyllycaconitine citrate hydrate (MLA), dihydro-beta-erythroidine hydrobromide (DHβE), and desipramine hydrochloride were purchased from Sigma (St. Louis, MO), sertraline hydrochloride from Toronto Research Chemicals (Ontario, Canada), varenicline tartrate from Allichem (Savage, MD) and 5-Iodo-A-85380 (5-I-A85380) dihydrochloride from Tocris Bioscience (Ellisville, MO). All drugs were dissolved in either saline, phosphate buffered saline, or injectable water and injected intraperitoneally (i.p) in a volume of 10 ml/kg. All doses are expressed as salt except for varenicline, which is expressed as the freebase.

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Caldarone B.J., Wang D., Paterson N.E., Manzano M., Fedolak A., Cavino K., Kwan M., Hanania T., Chellappan S.K., Kozikowski A.P., Olivier B., Picciotto M.R, & Ghavami A. (2011). Dissociation between duration of action in the forced swim test and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology, 217(2), 199-210.

Publication 2011

Azetidin Beta erythroidine hydrobromide Citrate Desipramine hydrochloride Drugs Iodo Mecamylamine Methyllycaconitine Phosphate Saline Salt Sertraline hydrochloride Varenicline Varenicline tartrate

Corresponding Organization :

Other organizations : University of Illinois at Chicago, Utrecht University, Yale University

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Variable analysis

independent variables

Sazetidine-A (6-(5-(S)-azetidin-2-yl)methoxypyridine-3-yl)hex-5-yn-1-ol)
Mecamylamine hydrochloride
Methyllycaconitine citrate hydrate (MLA)
Dihydro-beta-erythroidine hydrobromide (DHβE)
Desipramine hydrochloride
Sertraline hydrochloride
Varenicline tartrate
5-Iodo-A-85380 (5-I-A85380) dihydrochloride

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

positive controls

Not mentioned

negative controls

Not mentioned

Annotations

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