Peripheral venous blood samples were collected in fasting state within 1 week before initiation of chemotherapy in all patients. Peripheral neutrophil, lymphocyte and platelet counts were measured and analysed using an automated haematology analyser (Beckman Coulter LH750) and albumin levels were measured and analysed using an automated haematology analyser (Beckman Coulter AU5800), respectively. Referring to the results in our previous studies, in this study PNI was defined as PNI = albumin (g/L) + 5 × total lymphocyte count (109/L) and SII was defined as SII = platelets × neutrophil/lymphocyte count [28 (link), 29 (link)].
All patients were recommended to have an enhanced CT scan of the abdomen every 3 months for the first 3 years postoperatively and every 6 months for the 4–5th years. Follow-up methods mainly included telephone encounter, outpatient visits, and hospitalization. In this study, our primary observational endpoint was recurrence-free survival (RFS), defined as the time from the start of neoadjuvant therapy to the date of documented relapse or death from any cause at follow-up, and the follow-up deadline date for this study was January 31, 2022.
All patients were recommended to have an enhanced CT scan of the abdomen every 3 months for the first 3 years postoperatively and every 6 months for the 4–5th years. Follow-up methods mainly included telephone encounter, outpatient visits, and hospitalization. In this study, our primary observational endpoint was recurrence-free survival (RFS), defined as the time from the start of neoadjuvant therapy to the date of documented relapse or death from any cause at follow-up, and the follow-up deadline date for this study was January 31, 2022.
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