Prophylaxis in Transplant Recipients

As part of the prophylaxis based on the hospital formulary, recipients received meropenem (3 × 1 g), amikacin (15 mg/kg), and cloxacillin (4 × 1 g). Fluconazole (intravenous in 1st–3rd postoperative days), itraconazole (orally or through a probe), and voriconazole (orally and intravenous in CF patients or with history of Aspergillus fumigatus infection) were used as antifungal agents. Valganciclovir or ganciclovir were used as drugs active against cytomegalovirus. Topically, three agents were applied: amphotericin B (inhalation, 2 × 15 mg), nystatin (oral mucosa 4 × 1 mL suspension), and mupirocin (nasal vestibule twice a day). The basic set was used for a minimum of three days. It was modified depending on the recipient’s historical culture results or after obtaining the results of current microbiological tests. The first doses of antibiotics were administered intravenously in the operating theater before the beginning of the procedure. Antifungal drugs were introduced on the first postoperative day while antiviral agents were introduced within 10 days after the procedure.