All febrile (or those with history of fever in the last 48 h) participants admitted at the emergency ward and pediatric emergency ward of all ages were referred to the study team and seen on admission by a clinical staff of the study. Summary data were recorded on a pro-forma sheet. Only patients presenting with positive falciparum malaria test with clinical signs of severe illness (as described above, according to the WHO criteria [8 ]) were enrolled. These patients were examined by a physician and their data captured on a standardized form. The study was authorized by the Director of the hospital and approved by the Gabonese National Ethics Committee (PROTN°23/2019/PR/SG/CNER). Only children whose parents gave informed written consent were enrolled in the study. The rainfall dataset for this study was obtained from the Agence pour la sécurité de la navigation aérienne en Afrique et à Madagascar (ASECNA).Venous blood was collected for all enrolled patients for the following medical exam.
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