Optimized Protocol for In Vivo and Ex Vivo Drug Delivery

Um-PEA (0.8–6.0 μm) was kindly provided by EPITECH Group SpA, Saccolongo (PD). MPEP hydrochloride was purchased from Tocris Bioscience (Bristol, UK). MDCPG was purchased from Hello Bio (Bristol, UK). Drugs were dissolved in 0.05% dimethylsulfoxide in artificial cerebrospinal fluid (ACSF) on the day of the experiment. The dose of drugs was chosen according to our and otherin vivoandex vivostudies [17 (link),18 (link),27 (link),33 (link),47 (link),67 (link),74 (link),75 (link),76 (link)].

Free full text: Click here

Boccella S., Marabese I., Iannotta M., Belardo C., Neugebauer V., Mazzitelli M., Pieretti G., Maione S, & Palazzo E. (2019). Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain. International Journal of Molecular Sciences, 20(7), 1757.

Publication 2019

MPEP hydrochloride

Dimethylsulfoxide Drugs

Corresponding Organization :

Other organizations : University of Campania "Luigi Vanvitelli", Texas Tech University, Texas Tech University Health Sciences Center, Institute on Aging

Top 5 similar protocols

Variable analysis

independent variables

Um-PEA (0.8–6.0 μm) concentration
MPEP hydrochloride concentration
MDCPG concentration

dependent variables

Measured outcomes (not explicitly mentioned)

control variables

Dimethylsulfoxide concentration (0.05%) in artificial cerebrospinal fluid (ACSF)
Timing of drug administration (on the day of the experiment)

controls

Positive controls: Not explicitly mentioned
Negative controls: Not explicitly mentioned

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!