Automated Hippocampal and Amygdalar Volume Quantification

Two 3D T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) images (repetition time = 8.5 ms, echo time = 4 ms, flip angle = 8°, matrix dimensions 256 × 192, 184 contiguous sagittal 1.2-mm-thick slices, and time per acquisition = 5.4 min) were acquired on a whole-body Philips Intera 1.5-T MRI scanner (Philips, The Netherlands), and were averaged after motion correction.
Cerebral MRI data were preprocessed using Freesurfer v5.3 (http://surfer.nmr.mgh.harvard.edu/). Removal of non-brain tissues was manually performed on a slice-by-slice basis in each participant to increase the accuracy of segmentation. Volumetric measures (mm³) were obtained for left and right sides of the hippocampus and amygdala, two MTL regions that have shown reduced volume in aMCI patients that progressed to AD at 1-year follow-up29 (link).

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Prieto del Val L., Cantero J.L, & Atienza M. (2016). Atrophy of amygdala and abnormal memory-related alpha oscillations over posterior cingulate predict conversion to Alzheimer’s disease. Scientific Reports, 6, 31859.

Publication 2016

Intera 1.5-T MRI scanner

Amygdala Body Brain Echo Hippocampus Patients Tissues

Corresponding Organization :

Other organizations : Universidad Pablo de Olavide, Biomedical Research Networking Center on Neurodegenerative Diseases

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Volumetric measures (mm^3) of left and right sides of the hippocampus and amygdala

control variables

Repetition time = 8.5 ms
Echo time = 4 ms
Flip angle = 8°
Matrix dimensions 256 × 192
184 contiguous sagittal 1.2-mm-thick slices
Time per acquisition = 5.4 min
Whole-body Philips Intera 1.5-T MRI scanner (Philips, The Netherlands)

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