UK Biobank recruited over 500,000 participants aged 40-70 years from 2006 to 2010. A wide range of genetic and phenotypic data were collected at recruitment (baseline) and mortality and disease diagnoses were updated through linkages to death certificates, cancer registry and hospital admission records [24 (link), 25 (link)].
The DNA from blood samples was genotyped using Affymetrix UK BiLEVE Axiom array for the first ~50,000 participants and Affymetrix UK Biobank Axiom array for the rest of the cohort - the two arrays sharing over 95% marker content [25 (link)]. The two ApoE isoform coding SNPs, rs429358 and rs7412, on chromosome 19, were actually genotyped and the participant genotypes at these two locations were used to determine ApoE genotypes.
The DNA from blood samples was genotyped using Affymetrix UK BiLEVE Axiom array for the first ~50,000 participants and Affymetrix UK Biobank Axiom array for the rest of the cohort - the two arrays sharing over 95% marker content [25 (link)]. The two ApoE isoform coding SNPs, rs429358 and rs7412, on chromosome 19, were actually genotyped and the participant genotypes at these two locations were used to determine ApoE genotypes.
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