Bromocriptine Dissolution Comparison

Example 2

Solid samples of equal amounts of bromocriptine mesylate and bromocriptine citrate added, under various pH conditions, to equal volumes of water or water/organic solutions in different vessels and the dissolution of the bromocriptine samples (aqueous solubility) was assessed over time. Bromocriptine citrate was found to dissolve much more quickly and with significantly greater solubility (increased mg of bromocriptine dissolved per ml of water in the citrate vs mesylate salt form) compared to bromocriptine mesylate.

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US11878974B2. Composition and method for treating metabolic disorders (2024-01-23). VeroScience LLC [US]. Inventors: Anthony H. Cincotta [US].

Patent 2024

Bromocriptine Bromocriptine mesylate Citrate Mesylate Salt Vessels

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Variable analysis

independent variables

PH conditions

dependent variables

Dissolution of the bromocriptine samples (aqueous solubility)

control variables

Equal amounts of bromocriptine mesylate and bromocriptine citrate added
Equal volumes of water or water/organic solutions in different vessels

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