Genetic and Hematological Characteristics of Blood Donors

The NHLBI REDS-III RBC-Omics Study was a multi-center study enrolling 13,403 blood donors.^{20 (link)} This cohort was gen- otyped using a customized Affymetrix Axiom Array with approximately 879,000 single nucleotide polymorphisms (SNPs).^{22 (link)} Participants were stratified by sex and categorized into six groups that approximated the longitudinal groups (Figure 1B), differing by selection of females with a previous low hemoglobin deferral, instead of frequent first-time females, who could not be defined because of the cross-sectional study design. Groups 1 (2198 females) and 2 (1800 males) consisted of first-time or reactivated donors. Groups 3 (807 females) and 4 (183 males) had at least one low hemoglobin deferral in the previous 2 years. Groups 5 (818 females) and 6 (1652 males) had at least 8 whole blood donations within the prior 2 years. Iron supplement and cigarette use were obtained by survey.^{20 (link)} Ferritin and CBC were performed as described.^{20 (link),23 (link)}

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Mast A.E., Langer J.C., Guo Y., Bialkowski W., Spencer B.R., Lee T.H., Kiss J., Cable R.G., Brambilla D., Busch M.P, & Page G.P. (2020). Genetic and behavioral modification of hemoglobin and iron status among first-time and high-intensity blood donors. Transfusion, 60(4), 747-758.

Publication 2020

Axiom Array

Blood donations Blood donors Donors Females Ferritin Hemoglobin Iron Males Single nucleotide polymorphisms Supplement

Corresponding Organization : Medical College of Wisconsin

Other organizations : RTI International, American Red Cross, Pacific Research Institute, Vitalant

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Variable analysis

independent variables

Sex (female, male)
Hemoglobin deferral history (no deferral, at least one deferral in the previous 2 years, at least 8 whole blood donations within the prior 2 years)
Iron supplement use
Cigarette use

dependent variables

Genotyping using a customized Affymetrix Axiom Array with approximately 879,000 single nucleotide polymorphisms (SNPs)
Ferritin levels
Complete blood count (CBC)

control variables

None explicitly mentioned

controls

None explicitly mentioned

Annotations

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