Dietary Fiber Intervention for Youth Type 2 Diabetes

This was a pilot randomized double-blind crossover trial in Y-T2DM (Supplementary Figure S1). Youth aged 10–25 years, diagnosed with Y-T2DM by the American Diabetes Association criteria (27 (link)), Tanner stage IV or V, with Hemoglobin A1c (HbA1c) ≤8% were recruited to participate in this MIGHTY-Fiber Study. Exclusion criteria included: positive diabetes related autoantibodies (GAD-65 and IA-2 autoantibodies); consumption of ≥ 2 or more servings of ≥6 oz of yogurt per day; chronic GI disease; gastric bypass surgery; cancer diagnosis or auto-immune disease; chronic insulin therapy within 3 months of the study; or use of antibiotics, immunosuppressants, hormonal contraceptives, lipid-lowering agents, proton-pump inhibitors, supraphysiologic systemic steroids, cholesterol medications, prebiotics, or probiotics in the previous month at time of screening.

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Dixon S.A., Mishra S., Dietsche K.B., Jain S., Mabundo L., Stagliano M., Krenek A., Courville A., Yang S., Turner S.A., Meyers A.G., Estrada D.E., Yadav H, & Chung S.T. (2023). The effects of prebiotics on gastrointestinal side effects of metformin in youth: A pilot randomized control trial in youth-onset type 2 diabetes. Frontiers in Endocrinology, 14, 1125187.

Publication 2023

Antibiotics Auto immune disease Autoantibodies Cancer Cholesterol Chronic disease Contraceptives Diabetes Diagnosis Fiber Gad 65 Gastric bypass Gi disease Hemoglobin a1c Ia 2 autoantibodies Immunosuppressants Insulin Lipid lowering agents Medications Prebiotics Probiotics Proton pump inhibitors Steroids Surgery Therapy Yogurt Youth

Corresponding Organization : Children's National

Other organizations : National Institutes of Health Clinical Center

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Variable analysis

independent variables

Intervention (dietary fiber supplement vs. placebo)

dependent variables

Hemoglobin A1c (HbA1c)

control variables

Participants aged 10-25 years
Diagnosed with Y-T2DM by the American Diabetes Association criteria
Tanner stage IV or V
HbA1c ≤8%
Negative for diabetes-related autoantibodies (GAD-65 and IA-2 autoantibodies)
No consumption of ≥ 2 or more servings of ≥6 oz of yogurt per day
No chronic GI disease
No gastric bypass surgery
No cancer diagnosis or auto-immune disease
No chronic insulin therapy within 3 months of the study
No use of antibiotics, immunosuppressants, hormonal contraceptives, lipid-lowering agents, proton-pump inhibitors, supraphysiologic systemic steroids, cholesterol medications, prebiotics, or probiotics in the previous month at time of screening

controls

Placebo (control intervention)

Annotations

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