A specialist in nuclear medicine with 11 years of PET experience reviewed the FDG PET/CT images on a MIMvista workstation (ver. 6.5; MIM Software Inc, Cleveland, OH). All metabolic parameters were measured from the tumor volume segmented by a gradient-based method, as previously described.[22 (link),23 (link)] A gradient segmentation method is available in the MIMvista software with an operator-defined starting point near the center of the breast tumor lesion. Once the primary target lesion was segmented, SUVmax, mean standardized uptake value (SUVmean), MTV, and TLG were calculated automatically by the MIMvista software (Fig. 1 ). TLG was calculated by multiplying the SUVmean by the MTV. All SUVs were estimated based on injected dose and body weight.
All MR images were reviewed by a radiologist with 9 years of experience in interpreting breast imaging data. The lesion size was measured as the longest diameter of the lesion on the MIP image using a picture archiving and communication system workstation with electronic calipers. For multiple lesions, the longest diameter of each lesion was recorded separately and the sum of the lesions was calculated.
All MR images were reviewed by a radiologist with 9 years of experience in interpreting breast imaging data. The lesion size was measured as the longest diameter of the lesion on the MIP image using a picture archiving and communication system workstation with electronic calipers. For multiple lesions, the longest diameter of each lesion was recorded separately and the sum of the lesions was calculated.
