Protocol detail

Methamphetamine Self-Administration in Rats

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Methamphetamine from Sigma Chemical, Co., St Louis, MO, USA available in the operant cage for IV self-administration was 0.08 mg/kg per infusion with the maximum number of infusions obtainable in one session set to 50. The solutions were prepared for specific animals depending on their body weights rounded to the closest category of 250, 300, 350 g, etc. This paradigm is adapted from Emmett-Oglesby MW (Fort Worth, TX, USA) (30 (link)) and routinely used in our laboratory (17 (link), 31 (link)–33 (link)).

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Ruda-Kucerova J., Amchova P., Babinska Z., Dusek L., Micale V, & Sulcova A. (2015). Sex Differences in the Reinstatement of Methamphetamine Seeking after Forced Abstinence in Sprague-Dawley Rats. Frontiers in Psychiatry, 6, 91.

Publication 2015

Methamphetamine

Animals Body weights Methamphetamine Self administration

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Protocol cited in 1 other protocol

Variable analysis

independent variables

Dose of methamphetamine per infusion (0.08 mg/kg)

dependent variables

Number of infusions self-administered by animals

control variables

Maximum number of infusions obtainable in one session (50)
Preparation of solutions for specific animals based on their body weights rounded to the closest category of 250, 300, 350 g, etc.

controls

Positive control: Methamphetamine self-administration paradigm adapted from Emmett-Oglesby MW (Fort Worth, TX, USA)
Negative control: Not explicitly mentioned

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