Details of the CSF collection methods and CSF Aβ1–42, t-tau, and p-tau measurements are provided in the ADNI procedural manual and were described in a previous study [41 (link)]. The xMAP Luminex platform and Innogenetics/Fujirebio AlzBio3 Research Use Only immunoassay kits were used for CSF biomarker analysis. The cut-off values for CSF Aβ-positive (Aβ1–42 ≤ 192 pg/mL) were based on the previous studies [41 (link), 42 (link)].
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