Multimodal MRI Neuroimaging Protocol

Imaging data were acquired on a Magnetom Tim Trio 3T scanner (Siemens, Munich, Germany) using blood oxygen level-dependent (BOLD) and three-dimensional T1-weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) sequences. Scanning parameters for BOLD and three-dimensional (3D) T1 MPRAGE sequences are documented in our previous studies (Zhang et al., 2018 (link), 2020a; 2021 (link)). Briefly, for the BOLD sequence, the parameters were as follows: repetition time (TR) = 2,400 ms, echo time (TE) = 30 ms, field of view (FOV) = 230 mm × 230 mm, matrix size = 64 × 64, time points = 240, flip angle = 90°, and 40 axial slices. Patients were instructed to remain calm and awake with eyes closed during the resting-state fMRI scanning. For the 3D T1 MPRAGE sequence, the parameters were as follows: voxel size = 1.0 mm × 1.0 mm × 1.0 mm, FOV = 256 mm × 256 mm, matrix size = 256 × 256, thickness/gap = 1.0/0 mm, TR = 2,300 ms, TE = 2.98 ms, flip angle = 9°, and 176 sagittal slices.

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Kang Y.F., Chen R.T., Ding H., Li L., Gao J.M., Liu L.Z, & Zhang Y.M. (2022). Structure–Function Decoupling: A Novel Perspective for Understanding the Radiation-Induced Brain Injury in Patients With Nasopharyngeal Carcinoma. Frontiers in Neuroscience, 16, 915164.

Publication 2022

Magnetom Tim Trio 3T scanner

Blood oxygen level Echo Eyes Fmri Patients Trio

Corresponding Organization : Central South University

Other organizations : Shaanxi Normal University, Guilin Medical University, First Affiliated Hospital of GuangXi Medical University, Guangxi Medical University, Sun Yat-sen University Cancer Center, Sun Yat-sen University

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Variable analysis

independent variables

None explicitly mentioned.

dependent variables

None explicitly mentioned.

control variables

Magnetom Tim Trio 3T scanner (Siemens, Munich, Germany)
Blood oxygen level-dependent (BOLD) and three-dimensional T1-weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) sequences
Repetition time (TR) = 2,400 ms, echo time (TE) = 30 ms, field of view (FOV) = 230 mm × 230 mm, matrix size = 64 × 64, time points = 240, flip angle = 90°, and 40 axial slices for the BOLD sequence
Voxel size = 1.0 mm × 1.0 mm × 1.0 mm, FOV = 256 mm × 256 mm, matrix size = 256 × 256, thickness/gap = 1.0/0 mm, TR = 2,300 ms, TE = 2.98 ms, flip angle = 9°, and 176 sagittal slices for the 3D T1 MPRAGE sequence
Patients were instructed to remain calm and awake with eyes closed during the resting-state fMRI scanning.

positive controls

None mentioned.

negative controls

None mentioned.

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