Baicalin Magnesium Alleviates NASH in Rats

As shown in Fig. 2, rats were randomly divided into six groups with eight rats in each group, including the control group, model group, baicalin magnesium groups (50 mg/kg and 150 mg/kg), baicalin group (146.4 mg/kg) and MgSO₄ group (19.7 mg/kg). Baicalin magnesium and MgSO₄ were dissolved in sterilized water for injection. Baicalin was added to sterilized water for injection and then adjusted to pH 7.4 with 10% NaOH. The concentrations of baicalin magnesium, baicalin and MgSO₄ were 97 mg/ml, 188 mg/ml and 40 mg/ml, respectively. The baicalin group was administered a dose that was equimolar to the baicalin parent nucleus of baicalin magnesium (150 mg/kg), and the MgSO₄ group was administered equimolarly to the magnesium ion of baicalin magnesium (150 mg/kg). The tail vein of the control and model groups were injected with the same amount of saline as the administered group. After 1 week of normal feeding adaptation, rats (with the exception of the control group) were fed with HFD for 8 weeks to develop NASH, followed by 2 weeks of continuous HFD feeding. The rats were anesthetized by intraperitoneal injection of 1% thiopental sodium (50 mg/kg) [19 (link)], and the livers were removed to calculate the liver index and the ratio of liver mass to body mass. Blood was also collected for subsequent experiments.Fig. 2

Timeline demonstrating the induction of NASH and treatment. (BA-Mg: baicalin magnesium; BA: baicalin)