Postoperative Pain Management in Gynecological Cancer

Patients undergoing elective exploratory laparotomy for gynecological cancer were screened and enrolled between August 23, 2021 and February 10, 2022. Inclusion criteria were patients aged 20–60 years; American Society of Anesthesiologists physical status I or II; cognitive capacity to use the patient-controlled analgesia (PCA). The exclusion criteria were as follows: bronchial asthma; coronary heart disease; severe hypertension; diabetes mellitus; obesity (BMI >30 kg/m²); cardiac, hepatic, and renal dysfunction; psychiatric disease; history of chronic pain; history of alcohol or opioid abuse; chronic use of opioids; intake of any analgesic within 48 h before surgery; pregnancy; allergy and contraindication to any drug used in the study; local infection at the TAP block site; contraindication for the use of PCA; or incapacity to comprehend pain assessment. After randomization and allocation, patients were withdrawn if re-detection for postoperative bleeding or if protocol was violation.

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Zhang L., Jia Z., Gao T., Wang Y., Zhao Y., Li J., Yu Y., Li Q, & Wang G. (2023). A randomized controlled trial evaluating the effects of transversus abdominis plane block with compound lidocaine hydrochloride injection on postoperative pain and opioid consumption and gastrointestinal motility in patients undergoing gynecological laparotomy. Frontiers in Molecular Neuroscience, 16, 967917.

Publication 2023

Alcohol Allergy Analgesic Anesthesiologists Bronchial asthma Cancer Cardiac Chronic pain Cognitive Coronary heart disease Diabetes mellitus Hypertension Infection Laparotomy Obesity Opioid abuse Opioids Pain assessment Patient controlled analgesia Patients Physical Pregnancy Psychiatric disease Renal dysfunction Surgery

Corresponding Organization : Tianjin Medical University General Hospital

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Variable analysis

independent variables

TAP block

dependent variables

Postoperative pain
Opioid consumption

control variables

Patients aged 20-60 years
American Society of Anesthesiologists physical status I or II
Cognitive capacity to use the patient-controlled analgesia (PCA)
Absence of bronchial asthma, coronary heart disease, severe hypertension, diabetes mellitus, obesity (BMI >30 kg/m^2), cardiac/hepatic/renal dysfunction, psychiatric disease, history of chronic pain/alcohol/opioid abuse, chronic use of opioids, intake of any analgesic within 48 h before surgery, pregnancy, allergy and contraindication to any drug used in the study, local infection at the TAP block site, contraindication for the use of PCA, or incapacity to comprehend pain assessment

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