The database cancer single-cell state atlas (SEA) (http://biocc.hrbmu.edu.cn/CancerSEA/) was created to examine distinct functional states at the single cell level, and contains data on 14 functional states, including metastasis, invasion, apoptosis, cell cycle, differentiation, DNA damage, DNA repair, inflammation, and DNA damage.[19 ] We investigated the distribution and associated functions of complement C1q A chain (C1qA), complement C1q B chain (C1qB), and complement C1q C chain (C1qC) in SKCM using the Cancer SEA database.