Standardized Neurological Evaluation of HIV-SN

Physicians and nurses trained in neurological AIDS disorders performed a standardized, targeted neurological examination to evaluate HIV-SN signs, including diminished ability to recognize vibration and reduced sharp-dull discrimination in the feet and toes or reduced ankle reflexes. The presence of at least 1 sign bilaterally was considered to be evidence of HIV-SN. For confirmatory analyses, amore stringent criterion of 2 or more signs was used. Neuropathy symptoms also were assessed in the legs, feet, and toes and included bilateral neuropathic pain and dysesthesias (burning, aching, or shooting), paresthesias, and loss of sensation. Using a standardized form and a structured interview, clinicians classified neuropathic pain into the following 5 severity levels: none, slight (occasional, fleeting), mild (frequent), moderate (frequent, disabling), and severe (constant, daily, disabling, requiring analgesic medication or other treatment).

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Ellis R.J., Rosario D., Clifford D.B., McArthur J.C., Simpson D., Alexander T., Gelman B.B., Vaida F., Collier A., Marra C.M., Ances B., Atkinson J.H., Dworkin R.H., Morgello S, & Grant I. (2010). Continued High Prevalence and Adverse Clinical Impact of Human Immunodeficiency Virus–Associated Sensory Neuropathy in the Era of Combination Antiretroviral Therapy. Archives of neurology, 67(5), 552-558.

Publication 2010

Aids disorders Analgesic medication Ankle Discrimination Dysesthesias Feet Legs Neurological examination Neuropathic pain Nurses Paresthesias Physicians Toes Vibration

Corresponding Organization :

Other organizations : University of California, San Diego, Washington University in St. Louis, Johns Hopkins University, Icahn School of Medicine at Mount Sinai, The University of Texas Medical Branch at Galveston, University of Washington, University of Rochester

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Protocol cited in 13 other protocols

Variable analysis

independent variables

None explicitly mentioned

dependent variables

Diminished ability to recognize vibration in the feet and toes
Reduced sharp-dull discrimination in the feet and toes
Reduced ankle reflexes
Bilateral neuropathic pain
Bilateral dysesthesias (burning, aching, or shooting)
Bilateral paresthesias
Bilateral loss of sensation
Neuropathic pain severity levels (none, slight, mild, moderate, severe)

control variables

Physicians and nurses trained in neurological AIDS disorders performed a standardized, targeted neurological examination

positive controls

None explicitly mentioned

negative controls

None explicitly mentioned

Annotations

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