For pretreatment with amitriptyline before scald, mice were injected intraperitoneally with 10 mg/kg amitriptyline (Sigma-Aldrich, St. Louis, MO) twice daily for 2 days as previously described (23 (link)). The last dose was given 1 h before injury. Mice were weighed 24 h following scald or sham treatment. Elavil (amitriptyline HCI) dosage for outpatients ranges from 75 mg to 150 mg a day while hospitalized patients may require 100 mg to 300 mg a day.
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Amitriptyline Pretreatment for Scald Injury in Mice
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Corresponding Organization :
Other organizations : University of Duisburg-Essen, Sabin Vaccine Institute, University of Cincinnati Medical Center
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Variable analysis
independent variables
- Amitriptyline dose (10 mg/kg)
- Amitriptyline administration frequency (twice daily for 2 days)
- Time of last amitriptyline dose (1 h before injury)
- Mouse weight (24 h following scald or sham treatment)
- Mouse species (mice)
- Route of amitriptyline administration (intraperitoneal injection)
- Positive control: Scald injury
- Negative control: Sham treatment
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