Harmonized Multimodal Brain Imaging Protocols

We analyzed T1‐ and T2‐weighted fluid attenuated inversion recovery (FLAIR) scans acquired across seven MRI scanners. KLOSCAD and H70 Study used Philips 3T Achieva scanners (Philips Medical Systems),
¹⁹ (link),
²³ (link) and PATH used a Philips 1.5T Gyroscan scanner.
²² (link) Of the 474 MAS participants, 240 were scanned with a Philips 3T Intera Quasar scanner, and the remaining 234 with a Philips 3T Achieva Quasar Dual scanner.
²¹ (link) SLAS‐I and SLAS‐II used a Siemens 3T Tim Trio and a GE Healthcare 1.5T HDXT scanner, respectively. Detailed imaging acquisition parameters are summarized in Table S1 in supporting information.

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Lin K., Wen W., Lipnicki D.M., Mewton L., Chen R., Du J., Wang D., Skoog I., Sterner T.R., Najar J., Kim K.W., Han J.W., Kim J.S., Ng T.P., Ho R., Chua D.Q., Anstey K.J., Cherbuin N., Mortby M.E., Brodaty H., Kochan N., Sachdev P.S, & Jiang J. (2024). Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: The COSMIC consortium. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 16(1), e12567.

Publication 2024

Philips 3T Achieva scanners 1.5T Gyroscan scanner Intera Quasar scanner 3T Tim Trio 1.5T HDXT scanner

Corresponding Organization : UNSW Sydney

Other organizations : Commonwealth Scientific and Industrial Research Organisation, University of Gothenburg, Sahlgrenska University Hospital, Karolinska Institutet, Stockholm University, Amsterdam University Medical Centers, Seoul National University Bundang Hospital, Seoul National University, Khoo Teck Puat Hospital, Geriatric Education and Research Institute, National University of Singapore, Neuroscience Research Australia, Australian National University, Prince of Wales Hospital

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Variable analysis

independent variables

MRI scanner type

dependent variables

T1-weighted FLAIR scans
T2-weighted FLAIR scans

control variables

Imaging acquisition parameters (summarized in Table S1)

controls

No positive or negative controls were explicitly mentioned in the provided information.

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