Controlled-release silk hydrogel BioDomes

The BioDomes were composed of a soft silicon insert that contained silk hydrogels as a controlled-release substrate and drug carrier. The fabrication of the device has been reported elsewhere (34 (link)). Briefly, the outer cylindrical silicon sleeve (20-mm H × 18-mm D) was fabricated by casting silicon elastomer (Dragon skin 10, Smooth-on, Macungie, PA) against a 3D-printed mold, which was designed using CAD software (SolidWorks, Waltham, MA, USA) and printed using a Formlabs 3D printer (Somerville, MA, USA).

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Murugan N.J., Vigran H.J., Miller K.A., Golding A., Pham Q.L., Sperry M.M., Rasmussen-Ivey C., Kane A.W., Kaplan D.L, & Levin M. (2022). Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis. Science Advances, 8(4), eabj2164.

Publication 2022

Dragon skin 10 3D printer

Device Drug carrier Elastomer Hydrogels Mold Silicon Silk Skin

Corresponding Organization : Tufts University

Top 5 similar protocols

Variable analysis

independent variables

Fabrication of the outer cylindrical silicon sleeve (20-mm H × 18-mm D) by casting silicon elastomer (Dragon skin 10, Smooth-on, Macungie, PA) against a 3D-printed mold

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

No positive or negative controls were explicitly mentioned in the provided information.

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!