Remission Criteria in Hematological Malignancies

Complete remission (CR) was defined as the morphological recovery evidenced by less than 5% blasts according to bone marrow biopsy with complete hematological recovery. CR with incomplete count recovery (CRi) was defined as the morphological recovery evidenced by less than 5% blasts according to bone marrow biopsy, but with absolute neutrophil count (ANC) ≤ 1,000/µL or platelets ≤ 100,000/µL. ORR was comprised of CR and CRi. Morphological leukemia-free state (MLFS) was defined as morphological recovery without hematological recovery (ANC ≤ 1,000/µL and platelets ≤ 100,000/µL) [14 (link)]. Transfusion independence was defined as any 8-week period where the patient did not require blood or platelet transfusions. Clinical benefit was characterized by achievement of response (CR, CRi, or MLFS) or transfusion independence.

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Freeman T., Williams K., Puto M., Waller A., McLaughlin E.M., Blachly J.S, & Roddy J. (2023). Real-World Experience of Adults With Acute Myeloid Leukemia on Hypomethylating Agents With or Without Venetoclax at a Comprehensive Cancer Center. World Journal of Oncology, 14(1), 40-50.

Publication 2023

Biopsy Blood Bone marrow Leukemia Neutrophil Patient Platelet transfusions Platelets Transfusion

Corresponding Organization :

Other organizations : The Ohio State University

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Complete remission (CR) defined as morphological recovery evidenced by less than 5% blasts according to bone marrow biopsy with complete hematological recovery
CR with incomplete count recovery (CRi) defined as morphological recovery evidenced by less than 5% blasts according to bone marrow biopsy, but with absolute neutrophil count (ANC) ≤ 1,000/µL or platelets ≤ 100,000/µL
Overall response rate (ORR) comprised of CR and CRi
Morphological leukemia-free state (MLFS) defined as morphological recovery without hematological recovery (ANC ≤ 1,000/µL and platelets ≤ 100,000/µL)
Transfusion independence defined as any 8-week period where the patient did not require blood or platelet transfusions
Clinical benefit characterized by achievement of response (CR, CRi, or MLFS) or transfusion independence

control variables

Not explicitly mentioned

positive controls

Not mentioned

negative controls

Not mentioned

Annotations

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