High-Resolution MRI of MS Brain Tissue

Postmortem MRI scans from MS brains were acquired as previously described^{27 (link)}. Briefly, formalin-fixed brains were positioned in a Fomblin-filled container and were scanned in a 7-tesla MRI scanner (Siemens) equipped with a birdcage-type transmit coil and a 32-channel receive coil. A 3D T1w magnetization-prepared rapid gradient echo (T1-MP2RAGE, repetition time = 2200 ms, echo time = 3.04 ms, flip angle = 7 degrees, nominal resolution. 0.6×0.6×0.6 mm³, acquisition time: 6 minutes, 35 seconds) and a 3D high-resolution multigradient-echo (GRE, repetition time = 60 ms, echo times = 6.09, 15.99, 25.89, and 35.79 ms, flip angle = 10 degrees, nominal resolution. 0.42×0.42×0.42 mm³, acquisition time: 2 hours, 15 minutes) T2*w sequence were acquired.

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Ineichen B.V., Cananau C., Plattén M., Ouellette R., Moridi T., Frauenknecht K.B., Okar S.V., Kulcsar Z., Kockum I., Piehl F., Reich D.S, & Granberg T. (2023). Dilated Virchow-Robin Spaces are a Marker for Arterial Disease in Multiple Sclerosis. bioRxiv.

Publication Preprint 2023

7-tesla MRI scanner 32-channel receive coil

Brains Echo Formalin Postmortem Scanned mri Seconds

Corresponding Organization :

Other organizations : Karolinska University Hospital, Karolinska Institutet, University of Zurich, University Hospital of Zurich, Stockholm Health Care Services, Laboratoire National de Santé, National Institute of Neurological Disorders and Stroke

Top 5 similar protocols

Variable analysis

independent variables

Magnetic field strength (7-tesla)

dependent variables

T1-weighted magnetization-prepared rapid gradient echo (T1-MP2RAGE) images
High-resolution multigradient-echo (GRE) T2*-weighted images

control variables

Formalin-fixed brains
Fomblin-filled container
Birdcage-type transmit coil
32-channel receive coil
Repetition time (T1-MP2RAGE: 2200 ms, GRE: 60 ms)
Echo time (T1-MP2RAGE: 3.04 ms, GRE: 6.09, 15.99, 25.89, 35.79 ms)
Flip angle (T1-MP2RAGE: 7 degrees, GRE: 10 degrees)
Nominal resolution (T1-MP2RAGE: 0.6×0.6×0.6 mm^3, GRE: 0.42×0.42×0.42 mm^3)
Acquisition time (T1-MP2RAGE: 6 minutes, 35 seconds, GRE: 2 hours, 15 minutes)

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