The following drugs were used in the present study: clonidine, dexmedetomidine, yohimbine, GR73632, SR141716A, FPL64176, thapsigargin, and ZD7288 were purchased from Tocris (Minneapolis, MN, USA); McN-A-343, quinpirole HCl, and rolipram were purchased from Sigma-Aldrich (St. Louis, MO, USA); 2-methyl-serotonin maleate salt (2-Methyl-5-HT) was purchased from Santa Cruz Biotechnology (Dallas, TX, USA). SR141716A was dissolved to twice the stated drug dose in a 1:1:18 solution of ethanol:Emulphorâ„¢:0.9% saline and was then diluted further with an equal volume of saline. FPL64176 was dissolved in 25% DMSO in water. thapsigargin was dissolved in 10% DMSO in distilled water. Other drugs were dissolved in distilled water. All drugs were administered at a volume of 0.1 mL/10 g of body weight. The doses and routes used for the emetogens were based upon previous publications from our laboratory [6 (link),43 (link),87 (link)].
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