Dried blood spots were examined as described previously [18 (link)]. All three markers HBsAg, anti-HBc and anti-HBs tests (Abbott-Murex, United Kingdom) were performed according to the manufacturers’ instructions in 2160 individuals’samples. HBsAg-positive results were confirmed in the Murex HBsAg Confirmatory test, Version 3. HBsAg-positive samples from the 1985 (n = 84) and 2010 (n = 181) serum collections were screened for HDV with the anti-HDV total antibody test and HDAg detection tests (diaSorin, Italy).
Komas N.P., Ghosh S., Abdou-Chekaraou M., Pradat P., Al Hawajri N., Manirakiza A., Laghoe G.L., Bekondi C., Brichler S., Ouavéné J.O., Sépou A., Yambiyo B.M., Gody J.C., Fikouma V., Gerber A., Abeywickrama Samarakoon N., Alfaiate D., Scholtès C., Martel N., Le Gal F., Lo Pinto H., Amri I., Hantz O., Durantel D., Lesbordes J.L., Gordien E., Merle P., Drugan T., Trépo C., Zoulim F., Cortay J.C., Kay A.C, & Dény P. (2018). Hepatitis B and hepatitis D virus infections in the Central African Republic, twenty-five years after a fulminant hepatitis outbreak, indicate continuing spread in asymptomatic young adults. PLoS Neglected Tropical Diseases, 12(4), e0006377.
Corresponding Organization : Université Paris Cité
Other organizations :
Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Hôpital de la Croix-Rousse, Agence de la Biomédecine, University of Bangui, Iuliu Hațieganu University of Medicine and Pharmacy
Types of serological tests (HBsAg, anti-HBc, anti-HBs)
dependent variables
Presence/absence of HBV infection markers (HBsAg, anti-HBc, anti-HBs)
Presence/absence of HDV infection (anti-HDV total antibody, HDAg)
control variables
Dried blood spot samples from 2160 individuals
Confirmation of HBsAg-positive results using Murex HBsAg Confirmatory test, Version 3
positive controls
HBsAg-positive samples from 1985 (n = 84) and 2010 (n = 181) serum collections
negative controls
Not explicitly mentioned
Annotations
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