To prepare the derivatives, abacavir, acyclovir, adefovir, amantadine, amprenavir, darunavir, didanosine, oseltamivir, penciclovir, and tenofovir were used as mother ligand molecules, respectively. The functional group of each mother ligand molecule was substituted by Cl, F, NCH3, N(CH3)2, OH-, NH2-, HOOC-, or NO- [40 ]. Since there were no methods to predict which functional group that could increase the antiviral activity, its selection was based on ‘trial and error’ principles.
Protocol detail
Antiviral Functional Group Substituents
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Corresponding Organization :
Other organizations : International Islamic University Chittagong, State University of Bangladesh, Bangladesh Council of Scientific and Industrial Research, University of Dhaka
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Variable analysis
independent variables
- Substitution of the functional group of each mother ligand molecule with Cl, F, NCH3, N(CH3)2, OH-, NH2-, HOOC-, or NO-
- Antiviral activity of the derivative molecules
- Not explicitly mentioned
- No positive or negative controls were specified by the authors.
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