Platelet Transfusion Regimens for Surgery

We will include RCTs, non-RCTs and controlled before-after studies (CBAs) comparing three types of platelet transfusion regimens.
Comparison 1:. Prophylactic platelet transfusion prior to surgery versus no prophylactic platelet transfusion prior to surgery (placebo or no treatment).
Comparison 2: Prophylactic platelet transfusion prior to surgery versus alternative treatments (cryosupernatant, antifibrinolytics, thrombopoietin (TPO) mimetics). In this review we will exclude trials that assess the use of recombinant factor VIIa (rFVIIa); fibrinogen concentrate, recombinant factor XIII (rFXIII), prothrombin complex concentrate, and desmopressin as these are the subject of other Cochrane reviews that compared these interventions to an active comparator in people requiring a surgical procedure (Desborough 2017 (link); Fabes 2013 (link); Simpson 2012 (link)).
Comparison 3: Different platelet count thresholds for administering a prophylactic platelet transfusion prior to surgery.
We will record type of platelet component and dose of platelet component received.

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Estcourt L.J., Malouf R., Doree C., Trivella M., Hopewell S, & Birchall J. (2017). Prophylactic platelet transfusions prior to surgery for people with a low platelet count. The Cochrane Database of Systematic Reviews, 2017(9), CD012779.

Publication 2017

Antifibrinolytics Desmopressin Factor xiii Fibrinogen Placebo Platelet Platelet count Platelet transfusion Prophylactic Prothrombin complex concentrate Regimens Rfviia Surgery Thrombopoietin

Corresponding Organization :

Other organizations : NHS Blood and Transplant, John Radcliffe Hospital, University of Oxford, Nuffield Orthopaedic Centre, North Bristol NHS Trust

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Protocol cited in 2 other protocols

Variable analysis

independent variables

Prophylactic platelet transfusion prior to surgery
No prophylactic platelet transfusion prior to surgery (placebo or no treatment)
Alternative treatments (cryosupernatant, antifibrinolytics, thrombopoietin (TPO) mimetics)
Different platelet count thresholds for administering a prophylactic platelet transfusion prior to surgery

dependent variables

Unspecified

control variables

Type of platelet component
Dose of platelet component received

positive controls

Prophylactic platelet transfusion prior to surgery

negative controls

No prophylactic platelet transfusion prior to surgery (placebo or no treatment)

Annotations

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