The primary objectives of the CNSR-III were to establish Chinese ischaemic cerebrovascular disease aetiology classification cohort based on standard diagnosis procedures, identify imaging and biological markers for prognosis of the patients with ischaemic stroke and further establish the predictive model of stroke recurrence based on imaging and biological markers in ischaemic cerebrovascular diseases. The secondary objectives included evaluationĀ of the association of chronic kidney disease (CKD), abnormal glucose regulation, oxidative stress, homocysteine, intestinal flora, heart rate variability and outcome of ischaemic cerebrovascular diseases and its subtypes.