Mice used in this project were bred and maintained at the Little France animal unit at the University of Edinburgh. C57BL6/J mice of both sexes were used in all experiments. Animal care and procedures were carried out in accordance with the UK Animals (Scientific Procedures) Act of 1986 (ASPA) and the University of Edinburgh Ethical Review policy. Mice were housed in temperature- and humidity-controlled environment with 12-h light/darkness cycles, cage enrichment, and food and water available ad libitum.
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