Subcutaneous Microcirculation Measurement

We assessed the blood circulation function in all mice through subcutaneous microcirculation measurement. A laser Doppler imager (Moor Instruments, Axminister, UK) was used to scan the regional dermal microvascular blood flow of mice in the sham, GEG, DOX, and DOX + GEG treatment groups individually. The methods of subcutaneous microcirculation measurement used in this study mainly followed the methods of our previous study [39 (link)]. We selected and averaged the subcutaneous microcirculation measurements for each mouse obtained from at least three stable consecutive laser Doppler images.

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Lien C.Y., Lu C.W., Lin Y.H., Wu W.J., Hsu C.H., Chuang T.Y., Lin K.F., Chuang W.C., Lee M.C, & Wu C.H. (2021). Chinese Herbal Medicine, Guilu Erxian Glue, as Alternative Medicine for Adverse Side Effects of Chemotherapy in Doxorubicin-Treated Cell and Mouse Models. Evidence-based Complementary and Alternative Medicine : eCAM, 2021, 5548968.

Publication 2021

laser Doppler imager

Function blood Mice Microcirculation Mouse Scan

Corresponding Organization : National Taiwan Normal University

Other organizations : National Taiwan University, National Tsing Hua University

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Variable analysis

independent variables

Treatment group (sham, GEG, DOX, DOX + GEG)

dependent variables

Subcutaneous microvascular blood flow

control variables

Laser Doppler imager (Moor Instruments, Axminister, UK) used to scan the regional dermal microvascular blood flow
Methods of subcutaneous microcirculation measurement followed the methods of a previous study [39]
Subcutaneous microcirculation measurements were selected and averaged from at least three stable consecutive laser Doppler images for each mouse

controls

Sham treatment group (presumably a negative control)

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