Cued and contextual fear conditioning assays were initiated at the tunnel facility in 9.5- and 14.5-month-old animals using an automated fear conditioning chamber (MedAssociates, Inc.), as previously described (Berg et al. 2020 (link)). Briefly, rats were trained on day one with three tone-shock pairings of 30 s of white noise at 80 dB and a 2-s foot shock of . Contextual conditioning was assessed on day 2, and cued conditioning on day 3. Average motion index was measured automatically using VideoFreeze® software (version 2.7; MedAssociates).
Protocol detail
Cued and Contextual Fear Conditioning in Rats
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Corresponding Organization : University of California, Davis
Other organizations : Quality Research
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Variable analysis
independent variables
- Age of animals (9.5 months vs. 14.5 months)
- Average motion index (measured automatically using VideoFreeze® software)
- Tone-shock pairings (3 trials of 30 s white noise at 80 dB and 2-s foot shock of 0.7 mA)
- Conditioning protocol (cued and contextual fear conditioning)
- Positive control: Not explicitly mentioned.
- Negative control: Not explicitly mentioned.
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