Genetic Analysis of Asthma Cohorts

Asthma cases, unaffected controls, asthmacase parent trios, and extended families were recruited in clinics in the U.S, Mexico, and Barbados. Twelve samples with GWAS data were included in this study (Table 1). Detailed descriptions of the individual studies, ascertainment schemes, genotyping platforms, quality control (QC) protocols, and statistical analyses for the primary association testing are described in the Supplementary Note online.

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Torgerson D.G., Ampleford E.J., Chiu G.Y., Gauderman W.J., Gignoux C.R., Graves P.E., Himes B.E., Levin A.M., Mathias R.A., Hancock D.B., Baurley J.W., Eng C., Stern D.A., Celedón J.C., Rafaels N., Capurso D., Conti D.V., Roth L.A., Soto-Quiros M., Togias A., Li X., Myers R.A., Romieu I., Van Den Berg D.J., Hu D., Hansel N.N., Hernandez R.D., Israel E., Salam M.T., Galanter J., Avila P.C., Avila L., Rodriquez-Santana J.R., Chapela R., Rodriguez-Cintron W., Diette G.B., Adkinson N.F., Abel R.A., Ross K.D., Shi M., Faruque M.U., Dunston G.M., Watson H.R., Mantese V.J., Ezurum S.C., Liang L., Ruczinski I., Ford J.G., Huntsman S., Chung K.F., Vora H., Li X., Calhoun W.J., Castro M., Sienra-Monge J.J., del Rio-Navarro B., Deichmann K.A., Heinzmann A., Wenzel S.E., Busse W.W., Gern J.E., Lemanske R.F., Beaty T.H., Bleecker E.R., Raby B.A., Meyers D.A., London S.J., Gilliland F.D., Burchard E.G., Martinez F.D., Weiss S.T., Williams L.K., Barnes K.C., Ober C, & Nicolae D.L. (2011). Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations. Nature genetics, 43(9), 887-892.

Publication 2011

Asthma Extended families Gwas Parent Trios

Corresponding Organization :

Other organizations : RTI International, University of Chicago, Wake Forest University, Westat (United States), University of Southern California, University of California, San Francisco, University of Arizona, Harvard University Press, Henry Ford Health System, Johns Hopkins University, National Institutes of Health, University of Pittsburgh, Centre International de Recherche sur le Cancer, Northwestern University, United States Department of Veterans Affairs, Howard University, University of the West Indies System, Cleveland Clinic, Imperial College London, The University of Texas Medical Branch at Galveston, Washington University in St. Louis, University of Freiburg, University of Wisconsin–Madison

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Protocol cited in 37 other protocols

Variable analysis

independent variables

Asthma cases
Unaffected controls
Asthmacase parent trios
Extended families

dependent variables

GWAS data

control variables

Clinics in the U.S, Mexico, and Barbados

controls

No positive or negative controls are explicitly mentioned in the provided information.

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