Participants included normal subjects and glaucoma patients. Normal subjects were those without significant ocular disease (except for mild cataract) and with normal VF test results that were defined as a pattern standard deviation (PSD) > 5% and glaucoma hemifield test (GHT) within normal limits.28 (link) Glaucoma patients included those with any form of chronic glaucoma except for traumatic glaucoma and were defined as having characteristic glaucomatous disc abnormality with corresponding VF loss. The VF was considered abnormal if three or more contiguous test locations in the pattern deviation plot were depressed significantly at the P < 5% level with at least 1 at the P < 1% level on the same side of the horizontal meridian, or was classified as outside normal limits by the GHT.29 (link) If both eyes of one subject fit inclusion and exclusion criteria, one eye was selected randomly by using a random number generator statistical table.
Comprehensive Ocular Assessment of Glaucoma
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Corresponding Organization : Peking University People's Hospital
Other organizations : Vrije Universiteit Amsterdam
Protocol cited in 9 other protocols
Variable analysis
- Spherical equivalent between -5.0 diopters and +5.0 diopters
- Best corrected visual acuity of 20/40 or better
- Reliable visual field testing with acceptable fixation losses (<33%)
- False positives and false negatives (<20%)
- Visual field (VF) testing [Swedish Interactive Threshold Algorithm (SITA) 24-2 test of the Humphrey visual field analyzer 750i]
- Peri-papillary RNFL thickness measurements using the Spectralis OCT
- Absence of anterior segment dysgenesis
- Absence of corneal scarring or opacities
- Absence of proliferative or non-proliferative diabetic retinopathy
- Absence of field loss attributable to a non-glaucoma condition
- Dilated pupil diameter of at least 2 mm
- Normal subjects without significant ocular disease (except for mild cataract) and with normal visual field test results (pattern standard deviation > 5% and glaucoma hemifield test within normal limits)
- Glaucoma patients with characteristic glaucomatous disc abnormality and corresponding visual field loss
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