The availability of the analytical enforcement methods for the determination of residues of oxamyl according to the existing enforcement residue definition (i.e., oxamyl alone), was investigated both in the MRL review and in the EU pesticides peer review on the renewal of the approval of the active substance (EFSA, 2010 (link), 2022 (link)).
The MRL review concluded that suitable analytical methods are available for enforcement of parent oxamyl in commodities with high water content, high acid content and dry commodities at the validated LOQ of 0.01 mg/kg (EFSA, 2010 (link)). The availability of analytical enforcement method for the determination of residues in commodities of animal origin was not further investigated due to insignificant livestock exposure to oxamyl residues.
The EU pesticides peer review on the renewal of the approval concluded that oxamyl residues can be monitored in food and feed of plant origin by the quick, easy, cheap, effective and safe (QuEChERS) method using high‐performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) with a LOQ of 0.01 mg/kg in the four major plant matrices and dried tobacco leaf. The lack of studies on matrix effects and the verification of the extraction efficiency were identified as data gaps (EFSA, 2022 (link)). In food of animal origin oxamyl residues can be determined either by a multi‐residue QuEChERS method or by a single residue method using HPLC–MS/MS determination with a validated LOQ of 0.01 mg/kg in all animal matrices. Also, for these methods matrix effects were not examined and the extraction efficiency has not been verified (EFSA, 2022 (link)).
Noting potential consumer intake concerns related to oxamyl residues at the LOQ, the European Commission requested the EURLs to investigate whether a lower LOQs could be achieved in plant and animal matrices. The EURLs provided information that a lower LOQs could be achieved for the following crops/commodities:
The MRL review concluded that suitable analytical methods are available for enforcement of parent oxamyl in commodities with high water content, high acid content and dry commodities at the validated LOQ of 0.01 mg/kg (EFSA, 2010 (link)). The availability of analytical enforcement method for the determination of residues in commodities of animal origin was not further investigated due to insignificant livestock exposure to oxamyl residues.
The EU pesticides peer review on the renewal of the approval concluded that oxamyl residues can be monitored in food and feed of plant origin by the quick, easy, cheap, effective and safe (QuEChERS) method using high‐performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) with a LOQ of 0.01 mg/kg in the four major plant matrices and dried tobacco leaf. The lack of studies on matrix effects and the verification of the extraction efficiency were identified as data gaps (EFSA, 2022 (link)). In food of animal origin oxamyl residues can be determined either by a multi‐residue QuEChERS method or by a single residue method using HPLC–MS/MS determination with a validated LOQ of 0.01 mg/kg in all animal matrices. Also, for these methods matrix effects were not examined and the extraction efficiency has not been verified (EFSA, 2022 (link)).
Noting potential consumer intake concerns related to oxamyl residues at the LOQ, the European Commission requested the EURLs to investigate whether a lower LOQs could be achieved in plant and animal matrices. The EURLs provided information that a lower LOQs could be achieved for the following crops/commodities:
0.002 mg/kg in oranges and tomatoes.
0.001 mg/kg in commodities of high water and high acid content
0.005 mg/kg in avocados, cereals, meat of mammals
0.001 mg/kg in cow's milk.
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