For the TPOAb GWAS stage 1 and 2 analyses, and the hypothyroidism, hyperthyroidism and goiter analyses, individuals were recruited from 16 independent community-based and family studies. For the Graves' disease analyses, cases were recruited from the United Kingdom Graves' disease cohort and controls from the British 1958 Birth Cohort. Thyroid cancer cases and controls were recruited from the Nijmegen and Ohio thyroid cancer cohorts. A detailed description of the original cohorts contributing samples is provided in Table 1 and in the Supplementary Material. All participants provided written informed consent and protocols were approved by the institutional review boards or research ethics committees at the respective institutions, and conducted according to the Declaration of Helsinki.
Medici M., Porcu E., Pistis G., Teumer A., Brown S.J., Jensen R.A., Rawal R., Roef G.L., Plantinga T.S., Vermeulen S.H., Lahti J., Simmonds M.J., Husemoen L.L., Freathy R.M., Shields B.M., Pietzner D., Nagy R., Broer L., Chaker L., Korevaar T.I., Plia M.G., Sala C., Völker U., Richards J.B., Sweep F.C., Gieger C., Corre T., Kajantie E., Thuesen B., Taes Y.E., Visser W.E., Hattersley A.T., Kratzsch J., Hamilton A., Li W., Homuth G., Lobina M., Mariotti S., Soranzo N., Cocca M., Nauck M., Spielhagen C., Ross A., Arnold A., van de Bunt M., Liyanarachchi S., Heier M., Grabe H.J., Masciullo C., Galesloot T.E., Lim E.M., Reischl E., Leedman P.J., Lai S., Delitala A., Bremner A.P., Philips D.I., Beilby J.P., Mulas A., Vocale M., Abecasis G., Forsen T., James A., Widen E., Hui J., Prokisch H., Rietzschel E.E., Palotie A., Feddema P., Fletcher S.J., Schramm K., Rotter J.I., Kluttig A., Radke D., Traglia M., Surdulescu G.L., He H., Franklyn J.A., Tiller D., Vaidya B., de Meyer T., Jørgensen T., Eriksson J.G., O'Leary P.C., Wichmann E., Hermus A.R., Psaty B.M., Ittermann T., Hofman A., Bosi E., Schlessinger D., Wallaschofski H., Pirastu N., Aulchenko Y.S., de la Chapelle A., Netea-Maier R.T., Gough S.C., Meyer zu Schwabedissen H., Frayling T.M., Kaufman J.M., Linneberg A., Räikkönen K., Smit J.W., Kiemeney L.A., Rivadeneira F., Uitterlinden A.G., Walsh J.P., Meisinger C., den Heijer M., Visser T.J., Spector T.D., Wilson S.G., Völzke H., Cappola A., Toniolo D., Sanna S., Naitza S, & Peeters R.P. (2014). Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease. PLoS Genetics, 10(2), e1004123.
Other organizations :
University of Sassari, Institute of Genetic and Biomedical Research, Universität Greifswald, Sir Charles Gairdner Hospital, University of Washington, Helmholtz Zentrum München, Ghent University Hospital, Radboud University Nijmegen, Radboud University Medical Center, University of Helsinki, Churchill Hospital, Oxford Centre for Diabetes, Endocrinology and Metabolism, Capital Region of Denmark, Glostrup Hospital, University of Exeter, NIHR Exeter Clinical Research Facility, Martin Luther University Halle-Wittenberg, The Ohio State University, King's College London, McGill University, Helsinki University Hospital, Finnish Institute for Health and Welfare, University Hospital Leipzig, Wellcome Sanger Institute, Universitätsmedizin Greifswald, Pathwest Laboratory Medicine, Harry Perkins Institute of Medical Research, University of Western Australia, MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Michigan–Ann Arbor, Michigan United, Institute for Molecular Medicine Finland, Technical University of Munich, South Australia Pathology, The Lundquist Institute, UCLA Medical Center, Harbor–UCLA Medical Center, University of Birmingham, Royal Devon & Exeter NHS Foundation Trust, Ghent University, University of Copenhagen, Vaasa Central Hospital, Folkhälsans Forskningscentrum, Curtin University, Group Health Cooperative, Kaiser Permanente Washington Health Research Institute, Vita-Salute San Raffaele University, National Institute on Aging, IRCCS Materno Infantile Burlo Garofolo, University of Trieste, Netherlands Consortium for Healthy Ageing, Amsterdam UMC Location VUmc, University of Pennsylvania, Istituto di Genetica Molecolare
Recruitment of individuals from 16 independent community-based and family studies for the TPOAb GWAS stage 1 and 2 analyses, and the hypothyroidism, hyperthyroidism and goiter analyses
Recruitment of Graves' disease cases from the United Kingdom Graves' disease cohort and controls from the British 1958 Birth Cohort
Recruitment of thyroid cancer cases and controls from the Nijmegen and Ohio thyroid cancer cohorts
dependent variables
TPOAb levels (for GWAS analyses)
Hypothyroidism, hyperthyroidism, and goiter (for respective analyses)
Graves' disease
Thyroid cancer
control variables
All participants provided written informed consent
Protocols were approved by the institutional review boards or research ethics committees at the respective institutions
Protocols were conducted according to the Declaration of Helsinki
Annotations
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