Citicoline modulation of ECT-induced seizure

To examine the effect of citicoline in modulation of susceptibility to ECT-induced seizure [26 , 27 (link), 28 ], an electroconvulsive therapy apparatus (Model 7800, Ugo Basile, Camerio, Italy) was applied. Tonic convulsions of the hind extremities of mice were induced by passing alternating current (50 Hz, 50 mA and 0.2 s) via ear electrodes. In order to improve electrode contact, the electrodes were moistened with normal saline before being attached to the ears of mice. Electroshock induces a continuum of motor convulsions that are dependent on the intensity of the electrical stimulation current. The current used was predetermined before experimentation and was the current that caused hind limb extension in all mice in the trials. Data were expressed as the duration of tonic hind-limb extension (THE) after ECT.

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Rasooli R., Pirsalami F, & Moezi L. (2020). Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice. Heliyon, 6(5), e03932.

Publication 2020

Model 7800

Citicoline Ears Electrical stimulation Electroshock Hind limb Mice Motor convulsions Normal saline Seizure Susceptibility Tonic convulsions

Corresponding Organization : Shiraz University of Medical Sciences

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Variable analysis

independent variables

Citicoline

dependent variables

Duration of tonic hind-limb extension (THE) after ECT

control variables

Alternating current (50 Hz, 50 mA and 0.2 s) used to induce tonic convulsions
Electrodes moistened with normal saline before being attached to the ears of mice
Current used was predetermined before experimentation and was the current that caused hind limb extension in all mice in the trials

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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