Intranasal GW9508 administration in GMH model

Intranasal drug administration was conducted at 1 h, 25 h, and 49 h after GMH induction as described in (Zhang et al., 2017) [31 (link)]. A volume of 10 μl was administered of either 10% dimethyl sulfide (vehicle) or GW9508 (G9797, Sigma Aldrich, MO) at three different dosages (0.84 mg/kg, 2.5 mg/kg, 7.5 mg/kg). The dosage of GW9508 was adapted from previous literature [32 (link)].

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Xiao J., Cai T., Fang Y., Liu R., Flores J.J., Wang W., Gao L., Liu Y., Lu Q., Tang L., Zhang J.H., Lu H, & Tang J. (2021). Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model. Journal of Neuroinflammation, 18, 160.

Publication 2021

GW9508

Dimethyl sulfide Gw9508 Intranasal drug administration

Corresponding Organization : Third Xiangya Hospital

Other organizations : Loma Linda University

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Variable analysis

independent variables

Intranasal drug administration
Dosage of GW9508 (0.84 mg/kg, 2.5 mg/kg, 7.5 mg/kg)

dependent variables

Measured outcomes

control variables

Time points of intranasal drug administration (1 h, 25 h, 49 h after GMH induction)
Volume of intranasal administration (10 μl)
Vehicle (10% dimethyl sulfide)

controls

Positive control: Not specified
Negative control: 10% dimethyl sulfide (vehicle)

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