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Lymphoma Stromal Cells Promote Tumor Growth

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Lymphoma Stromal Cells (LSCs) Promote Lymphoma Development in a NO-Dependent Manner

To examine the effect of lymphoma stromal cells on tumor growth, 355 B-cell lymphoma cell line (C3H-gld/gld background, 0.5×10⁶cells/mouse) was co-injected with gld/gld mice-derived lymphoma stromal cells (C3H background, P5, 0.25×10⁶cells/mouse). It was observed that co-injection of stromal cells significantly enhanced the mortality. Interestingly, administration of 1400 W (NOS inhibitor, 0.1 mg/mouse on day 0, 2, 4, 8, 12, 16, 20, 24, and 28) significantly reverted the effect (FIG. 4). Therefore, the tumor stromal cells could significantly promote tumor growth.

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US11872250B2. Methods for inducing an immune response by administering activated mesenchymal stem cells (2024-01-16). Rutgers, The State University of New Jersey [US]. Inventors: Yufang Shi [US], Guangwen Ren [US], Liying Zhang [US].

Patent 2024

1400 w B cell lymphoma Cells Immune response Lymphoma Mesenchymal stem cells Mesenchymal stromal cells Mouse Stem cells Stromal cells Tumor

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Variable analysis

independent variables

Co-injection of lymphoma stromal cells (C3H background, P5, 0.25×10^6 cells/mouse) with 355 B-cell lymphoma cell line (C3H-gld/gld background, 0.5×10^6 cells/mouse)

dependent variables

Mortality

control variables

Administration of 1400 W (NOS inhibitor, 0.1 mg/mouse on day 0, 2, 4, 8, 12, 16, 20, 24, and 28)

controls

Positive control: Co-injection of lymphoma stromal cells (C3H background, P5, 0.25×10^6 cells/mouse) with 355 B-cell lymphoma cell line (C3H-gld/gld background, 0.5×10^6 cells/mouse)
Negative control: Administration of 1400 W (NOS inhibitor, 0.1 mg/mouse on day 0, 2, 4, 8, 12, 16, 20, 24, and 28)

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