Genetically Modified Mouse Models

All animal husbandry and procedures were performed in compliance with institutional animal care and committee guidelines. Gpr65-ires-Cre, Glp1r-ires-Cre, and Phox2b-Cre; loxP-Piezo1; loxP-Piezo2 mice were described before (Chang et al., 2015 (link); Williams et al., 2016 (link); Zeng et al., 2018 (link)); Vglut2-ires-Cre mice were a generous gift from Bradford Lowell (Beth Israel Deaconess Medical Center); and wild-type C57BL/6J (000664), Piezo2-EGfp-ires-Cre (027719), Mc4r-2a-Cre (030759), LoxP-ChR2 (012569), and LoxP-DTR (007900) mice were purchased (Jackson). Male and female mice between 8–16 weeks old were used for all studies, and no differences based on sex were observed.

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Min S., Chang R.B., Prescott S.L., Beeler B., Joshi N.R., Strochlic D.E, & Liberles S.D. (2019). Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws. Cell reports, 29(8), 2192-2201.e3.

Publication 2019

C57BL/6J Piezo2-EGfp-ires-Cre Mc4r-2a-Cre LoxP-ChR2 LoxP-DTR

Animal Female Ires Male Mc4r Mice

Corresponding Organization : Harvard University

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Variable analysis

independent variables

Gpr65-ires-Cre
Glp1r-ires-Cre
Phox2b-Cre; loxP-Piezo1; loxP-Piezo2
Vglut2-ires-Cre
Piezo2-EGfp-ires-Cre
Mc4r-2a-Cre
LoxP-ChR2
LoxP-DTR

dependent variables

Not explicitly mentioned

control variables

Wild-type C57BL/6J (000664) mice

controls

Positive controls: Not specified
Negative controls: Not specified

Annotations

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