Gellan Gum Scaffold for Tissue Engineering

All the reagents used in this study were of HPLC grade. Gellan gum (GG) (GelzanTM, Sigma-Aldrich Co., St. Louis, MI, USA) with an average molecular weight of 1,000,000 g/mole was purchased. PEG of [Poly (ethylene glycol)] (mw 6000, Sigma-Aldrich) and Trizol (Invitrogen, Life Technologies Co, Groningen, The Netherlands) were used. Hydroxyapatite (HA) nanoparticles were purchased from Sigma Aldrich (St Louis, MO, USA). The main characteristics of this HA powder were characterized by producer (mean diameter of about 70 nm, surface area of 27.6 m²/g, purity of 98.9%). Compound K solution was purchased commercially from general bio-Co. Ltd. (Gyeongcheon-myeon, Jeollabuk-do, Republic of Korea) and was completely characterized by the company in a previous research work [71 (link)].
All the scaffold components were previously used in tissue engineering and proved to be non-toxic [40 (link),47 (link),72 (link),73 (link)].

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Thangavelu M., Kim P.Y., Cho H., Song J.E., Park S., Bucciarelli A, & Khang G. (2024). A Gellan Gum, Polyethylene Glycol, Hydroxyapatite Composite Scaffold with the Addition of Ginseng Derived Compound K with Possible Applications in Bone Regeneration. Gels, 10(4), 257.

Publication 2024

Trizol Hydroxyapatite (HA) nanoparticles

Corresponding Organization :

Other organizations : Jeonbuk National University, Istituto Ortopedico Rizzoli

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Variable analysis

independent variables

Gellan gum (GG) concentration
Hydroxyapatite (HA) nanoparticles concentration
Compound K solution concentration

dependent variables

Characteristics of the HA powder (mean diameter, surface area, purity)

control variables

All reagents used were of HPLC grade
The scaffold components were previously used in tissue engineering and proved to be non-toxic

positive controls

None mentioned

negative controls

None mentioned

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