We prospectively identified consecutive patients presenting to the Royal Infirmary of Edinburgh, United Kingdom, from 1 August to 31 October 2012, in whom the attending doctor suspected an acute coronary syndrome. Patients not resident in the south east of Scotland were excluded from the study. We obtained information about the patients and their clinical outcomes through the TrakCare software application (InterSystems, Cambridge, MA) as previously described.9 (link)
10 (link)
Serum troponin concentrations were measured on admission and repeated six or 12 hours after the onset of symptoms13 (link)
14 (link) using both a contemporary sensitive troponin I assay and a high sensitivity troponin I assay. Clinical decisions were based on the results of the contemporary assay only, with clinicians blinded to the results of the high sensitivity assay.
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