Plasma HIV RNAandCD4+ cell count data obtained within the last 6 months and type of assay were abstracted from medical records. Because of the variability in type of assay used across the study sites (ie, Versant HIV-1 RNA 3.0 [Siemens Diagnostics]; Amplicor HIV-1 Monitor – Standard/Ultrasensitive [F. Hoffmann-La Roche Ltd]; COBAS AmpliPrep/COBAS Taqman HIV-1 Test, versions 1.0 and 2.0 [F. Hoffmann-La Roche Ltd]; and RealTime HIV-1 Assay [Abbott Laboratories]), we used the corresponding assay cutoff for the lower limit of HIV RNA detection (all were <200 copies/mL; see Kahana et al11 (link) for sensitivity analysis) and created a dichotomous variable to differentiate VL− and VL+ participants.
Protocol detail
Plasma HIV RNA and CD4+ Cell Count
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Assay
Diagnostics
Hiv 1
Hiv test
Plasma cell
Sensitivity
Corresponding Organization : Columbia University
Other organizations : National Institute on Drug Abuse, National Institutes of Health, Nova Southeastern University, University of Michigan–Ann Arbor, Fenway Health, Harvard University, University of Alabama at Birmingham, University of North Carolina at Chapel Hill
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Variable analysis
independent variables
- Type of assay used to measure Plasma HIV RNA
- Plasma HIV RNA
- CD4+ cell count
- Cutoff for the lower limit of HIV RNA detection (<200 copies/mL) across all assay types
- Dichotomous variable to differentiate VL- and VL+ participants
- No positive or negative controls were explicitly mentioned in the information provided.
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