Plasma Biomarkers for ARDS Diagnosis

Plasma levels of ten biomarkers with validated associations with ARDS were measured with a customized Luminex assay (R&D Systems, Minneapolis) (13 (link)) and classified into the following categories: a. innate immune responses (IL-6, IL-8, IL-10, TNFR1, suppression of tumorigenicity-2 [ST-2], fractalkine) (9 (link), 14 (link)–16 (link)), b. epithelial injury (receptor of advanced glycation end-products [RAGE]) (17 (link)), c. endothelial injury (Angiopoietin-2) (18 (link)) and, d. host-response to bacterial infections (procalcitonin and pentraxin-3) (19 (link), 20 (link)).

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Kitsios G.D., Yang L., Manatakis D.V., Nouraie M., Evankovich J., Bain W., Dunlap D.D., Shah F., Barbash I.J., Rapport S.F., Zhang Y., DeSensi R.S., Weathington N.M., Chen B.B., Ray P., Mallampalli R.K., Benos P.V., Lee J.S., Morris A, & McVerry B.J. (2019). ARDS subphenotypes beyond ARDS: prognostic enrichment in mechanically-ventilated patients with or at risk for ARDS.. Critical care medicine, 47(12), 1724-1734.

Publication 2019

Luminex

Advanced glycation end products receptor Angiopoietin 2 Ards Assay Bacterial infections Biomarkers Endothelial Fractalkine Host response Il 10 Injury Innate immune responses Pentraxin 3 Plasma Procalcitonin Tnfr1 Tumorigenicity

Corresponding Organization :

Other organizations : University of Pittsburgh Medical Center, University of Pittsburgh, VA Pittsburgh Healthcare System

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Protocol cited in 7 other protocols

Variable analysis

independent variables

Plasma levels of ten biomarkers: IL-6, IL-8, IL-10, TNFR1, ST-2, fractalkine, RAGE, Angiopoietin-2, procalcitonin, and pentraxin-3

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

No positive or negative controls were explicitly mentioned in the input protocol.

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