Amyloid PET Imaging with Pittsburgh Compound B

Amyloid PET imaging was performed using the Pittsburgh Compound B (PiB) tracer. Details on PiB‐PET imaging in the MCSA have been published elsewhere (33 (link), 34 (link)). Briefly, PiB scans, consisting of four 5‐min dynamic frames, were acquired 40–60 min after intravenous injection with 292–728 MBq of 11C‐PiB. We used an in‐house, fully automated image processing pipeline to analyze images. Herein, image voxel values were extracted from automatically labeled regions of interest (ROI) propagated from regions defined on each participant's own magnetic resonance imaging (MRI). The prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, and posterior cingulate/precuneus ROI were normalized to the cerebellar gray matter to form a global amyloid PET standardized uptake value ratio (SUVR). We defined abnormal PiB‐PET retention (PiB‐PET+) by an SUVR ≥1.48, which is the current cut‐off used in the MCSA (33 (link), 35 (link)). We ran the linear‐mixed effects models with continuous, z‐scored PiB‐PET SUVR.

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Pink A., Krell‐Roesch J., Syrjanen J.A., Christenson L.R., Lowe V.J., Vemuri P., Fields J.A., Stokin G.B., Kremers W.K., Scharf E.L., Jack CR J.r., Knopman D.S., Petersen R.C., Vassilaki M, & Geda Y.E. (2023). Interactions Between Neuropsychiatric Symptoms and Alzheimer's Disease Neuroimaging Biomarkers in Predicting Longitudinal Cognitive Decline. Psychiatric Research and Clinical Practice, 5(1), 4-15.

Publication 2023

11c pib Amyloid Anterior cingulate Cerebellar gray matter Frames Posterior cingulate regions Precuneus Retention Scans

Corresponding Organization :

Other organizations : Paracelsus Medical University, Mayo Clinic in Florida, Karlsruhe Institute of Technology, Mayo Clinic, Barrow Neurological Institute

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Variable analysis

independent variables

PiB-PET SUVR (continuous, z-scored)

dependent variables

Global amyloid PET standardized uptake value ratio (SUVR)

control variables

Prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, and posterior cingulate/precuneus ROIs were normalized to the cerebellar gray matter

controls

The current cut-off used in the MCSA for defining abnormal PiB-PET retention (PiB-PET+) is SUVR ≥1.48

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