Some patients receiving SEED-BT at institution A in 2006 were treated using preplanning methods. Most other patients at the 3 institutions were treated using an intraoperative planning method with modified peripheral loading techniques using a Mick applicator12 (link),13 (link). The therapeutic planning and post-implant dosimetric evaluation were performed using the Interplant planning system (CMS, St. Louis, MO) or Variseed (Varian, Palo Alto, CA). 125I was used for all patients. Either Oncoseed 6711 (GE Healthcare, Arlington Heights, IL) or STM 1251 (BD, Tempe, AZ) was used for SEED-BT. The doses were defined using the TG-43 criteria14 (link). At 1 month after treatment with SEED-BT alone, a computed tomography-based dosimetric analysis was performed to calculate the D90, V100, and V150 results. Prostate D90 is the minimum dose to 90% of the prostate gland at 1 month. Prostate V100 and V150 are the percentages of the prostate gland volume respectively receiving 100% and 150% of the prescribed dose at 1 month. These treatment protocols were used at each institution:
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